Publications

Lu YS, Hung WC, Hsieh YT, Tsai PY, Tsai TH, Fan HH, Chang YG, Cheng HK, Huang SY, Lin HC, Lee YH, Shen TH, Hung BY, Tsai JW, Dzhagalov I, Cheng IH, Lin CJ, Chern Y, Hsu CL.; Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model. Brain Behav Immun. 2024 Aug;120:413-429. doi: 10.1016/j.bbi.2024.06.021. PDF

Gainullina A, Mogilenko DA, Huang LH, Todorov H, Narang V, Kim KW, Yng LS, Kent A, Jia B, Seddu K, Krchma K, Wu J, Crozat K, Tomasello E, Dress R, See P, Scott C, Gibbings S, Bajpai G, Desai JV, Maier B, This S, Wang P, Aguilar SV, Poupel L, Dussaud S, Zhou TA, Angeli V, Blander JM, Choi K, Dalod M, Dzhagalov I, Gautier EL, Jakubzick C, Lavine K, Lionakis MS, Paidassi H, Sieweke MH, Ginhoux F, Guilliams M, Benoist C, Merad M, Randolph GJ, Sergushichev A, Artyomov MN; ImmGen Consortium; Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes. Cell Rep. 2023 Jan 27;42(2):112046. doi: 10.1016/j.celrep.2023.112046. PDF

Hsieh YT, Tsai TL, Huang SY, Heng JW, Huang YC, Tsai PY, Tu CC, Chao TL, Tsai YM, Chang PC, Lee CK, Yu GY, Chang SY, Dzhagalov IL; Hsu CL. IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. EMBO Rep. 2023 Jan 18:e55286. doi: 10.15252/embr.202255286. PDF

Tsai TL, Tsai PY, Dzhagalov IL, Hsu CL; Protocol for standardized intrathymic injection in mice. STAR Protoc. 2023 Jan 12;4(1):102010. doi: 10.1016/j.xpro.2022.102010. PDF

Zhou TA, Hsu HP, Tu YH, Cheng HK, Lin CY, Chen NJ, Tsai JW, Robey EA, Huang HC, Hsu CL, Dzhagalov IL; Thymic macrophages consist of two populations with distinct localization and origin. Elife. 2022 Nov 30;11:e75148. doi: 10.7554/eLife.75148. PDF

Herrera-Heredia SA, Hsu HP, Kao YC, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL; Heparin is required for the formation of granules in connective tissue mast cells. Front Immunol. 2022; Nov 09; 13:1000405. doi: 10.3389/fimmu.2022.1000405. PDF

Tsai TL, Zhou TA, Hsieh YT, Wang JC, Cheng HK, Huang CH, Tsai PY, Fan HH, Feng HK, Huang YC, Lin CC, Lin CH, Lin CY, Dzhagalov IL, Hsu CL; Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress. Cell Rep. 2022; Jul 12; 40(2):111065. doi:10.1016/j.celrep.2022.111065. PDF

Fan HH, Tsai TL, Dzhagalov IL, Hsu CL; Evaluation of Mitochondria Content and Function in Live Cells by Multicolor Flow Cytometric Analysis. Methods Mol Biol.2021;2276:203-213. doi: 10.1007/978-1-0716-1266-8_15. PDF

Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL; Heparan sulfate is essential for thymus growth. J Biol Chem. 2021 Feb 15:100419. doi: 10.1016/j.jbc.2021.100419. Online ahead of print. PDF

Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL; Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection. Front. Cell Dev. Biol. 8:586807. doi: 10.3389/fcell.2020.586807 PDF

Maslova A, Ramirez RN, Ma K, Schmutz H, Wang C, Fox C, Ng B, Benoist C, Mostafavi S; Immunological Genome Project. Deep learning of immune cell differentiation. Proc Natl Acad Sci U S A. 2020 Sep 25:202011795. doi: 10.1073/pnas.2011795117. PDF

Immunological Genome Project. ImmGen at 15. Nat Immunol. 2020 Jul;21(7):700-703. doi: 10.1038/s41590-020-0687-4. PDF

Chou YJ, Lin CC, Dzhagalov IL, Chen NC, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Sci Rep. 2020 May 21;10(1):8422. Doi: 10.1038/s41598-020-65422-1  PDF

Zhou TA, Hsu CL, Dzhagalov IL. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17. PDF

Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. A role for phagocytosis in inducing cell death during thymocyte negative selection. eLife. 2019 Dec 23;8. pii: e48097. doi: 10.7554/eLife.48097. PDF

Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL. Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Sci Rep. 2019 Oct 10;9(1):14547. doi: 10.1038/s41598-019-51020-3. PDF

Hsu CL and Dzhagalov IL Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Immunometabolism. 2019;1:e190012. https://doi.org/10.20900/immunometab20190012. PDF

Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. PDF

Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC, Yang AH, Lee HJ, Sung SH, Wang YF, Yu WC, Hsu TR, Huang PH, Chang SK, Dzhagalov I, Hsu CL, Niu DM. Identification of lysosomal and extralysosomal globotriaosylceramide (Gb3) accumulations before the occurrence of typical pathological changes in the endomyocardial biopsies of Fabry disease patients. Genet Med. 2019 Aug;21(8):1892-1893. doi: 10.1038/s41436-019-0437-x. PDF

Wei CW, Zhou TA, Dzhagalov IL, Hsu CL Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells. JOVE. 2019 Jan 9;(143). doi: 10.3791/58844. PDF

Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov IL, Hsu CL. Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability. Cell Rep. 2018 May 22;23(8):2330-2341. doi: 10.1016/j.celrep.2018.04.077. PDF